The aim of the study is to develop and evaluate the effectiveness of a new combined gel for the treatment of experimental stomatitis. The drug contains three active ingredients: standardized extract of Centella asiatica (a source of asiaticosides), high molecular weight hyaluronic acid, and lactoferrin. The study was conducted on a model of traumatic stomatitis in 45 male rabbits divided into three groups. The experimental group received the developed gel, the comparison group received a 0.05% chlorhexidine-based gel, and the control group received a saline solution. The results demonstrated statistically significant advantages of the developed gel. Complete epithelialization in the experimental group occurred on 7.4±0.9 days, which is 2.2 days faster than in the chlorhexidine group. By the fifth day, the area of the wound defect in the main group decreased by 78.2% of the initial one, whereas in the comparison group, this indicator was only 54.6%. Microbiological analysis revealed a decrease in contamination in the experimental group to 8.7±3.2 CFU/ml × 103 by day 10, which is 5.5 times lower than in the chlorhexidine group. Histologically, there was a decrease in inflammatory infiltration to 1.2±0.2 points and active formation of mature granulation tissue (3.6±0.3 points). The developed combined gel demonstrates pronounced regenerative, anti-inflammatory, and antimicrobial effects, surpassing the effectiveness of standard chlorhexidine therapy, and can be recommended for further research.
