TY  - JOUR
T1  - Optimization of Regeneration of Oral Mucosa: Development and Evaluation of the Effectiveness of the Combined Gel
A1  - Milana Arsenovna Dolova
A1  - Ruslan Kazbekovich Esiev
A1  - Salima Olegovna Karaeva
A1  - Veronika Robertovna Zakaeva
A1  - Fatima Kaimarazovna Tajudinova
A1  - Irina Sergeevna Voropaeva
A1  - Alifat Beslanovna Albogachieva
A1  - Bela Shamsudinovna Dzaurova
A1  - Malika Ruslanovna Abzotova
JF  - Annals of Dental Specialty
JO  - Ann Dent Spec
SN  - 2347-2022
Y1  - 2025
VL  - 13
IS  - 3
DO  - 10.51847/kRzCu3JZXB
SP  - 53
EP  - 60
N2  - The aim of the study is to develop and evaluate the effectiveness of a new combined gel for the treatment of experimental stomatitis. The drug contains three active ingredients: standardized extract of Centella asiatica (a source of asiaticosides), high molecular weight hyaluronic acid, and lactoferrin. The study was conducted on a model of traumatic stomatitis in 45 male rabbits divided into three groups. The experimental group received the developed gel, the comparison group received a 0.05% chlorhexidine-based gel, and the control group received a saline solution. The results demonstrated statistically significant advantages of the developed gel. Complete epithelialization in the experimental group occurred on 7.4±0.9 days, which is 2.2 days faster than in the chlorhexidine group. By the fifth day, the area of the wound defect in the main group decreased by 78.2% of the initial one, whereas in the comparison group, this indicator was only 54.6%. Microbiological analysis revealed a decrease in contamination in the experimental group to 8.7±3.2 CFU/ml × 103 by day 10, which is 5.5 times lower than in the chlorhexidine group. Histologically, there was a decrease in inflammatory infiltration to 1.2±0.2 points and active formation of mature granulation tissue (3.6±0.3 points). The developed combined gel demonstrates pronounced regenerative, anti-inflammatory, and antimicrobial effects, surpassing the effectiveness of standard chlorhexidine therapy, and can be recommended for further research.
UR  - https://annalsofdentalspecialty.net.in/article/optimization-of-regeneration-of-oral-mucosa-development-and-evaluation-of-the-effectiveness-of-the-pbttmtnm45cyih3
ER  -