Oral cancer is predicted to rank sixth globally in terms of cancer incidence, impacting nearly all homes and contributing to one in six fatalities. Physician knowledge of need to conduct proper oral exams is first line of defense against the development of this condition and its consequent cancers. Purpose of the present investigation is to assess medical students' awareness and general understanding of OC at rural hospital in central Maharashtra, India. 310 participants—including medical and dentistry students from all years—were sent invitation message that contained a URL link to the online survey. Cronbach's alpha value of 0.80 indicated that it had concept validity and internal consistency reliability. The demographic characteristics of age and gender were used to categorize respondents. Among the participants, 74.4% were female and 25.6% were male. Additionally, participants were examined across various age groups. The difference in opinions of responses was evaluated statistically for awareness among those posted in clinics as well as in preclinics. According to our survey, around 39% of respondents were vaccinated for HPV, and more females were aware of vaccination. In order to influence future work habits, this important training must begin in medical school. Research shows that because of a self-reported ignorance, majority of physicians do not regularly discuss HPV-positive HNC. It's also critical to look at how we are teaching the next generation of physicians about this pandemic. In order to diagnose, treat, and prevent OC, medical students pursuing separate specialization must be aware of and informed about disorder.