Bioactive materials are substances that affect living tissue, organisms, and cells or their response. The effectiveness of the use of these materials in various fields of dentistry and medicine is approved by many experts. The purpose of this research was to review the application and characteristics of bioactive materials in different fields of dentistry. In this study, several articles that were published on this topic in recent years and had valuable results were examined. In these studies, the use of bioactive materials in tooth remineralization for hard tissue regeneration, pulp capping treatment, and anti-caries and antibacterial properties were studied. Some of these substances have the properties of alkaline and convert acidic pH to neutral pH, while others have adhesive properties and chemical bonding. Dimensional stability, biocompatibility, and bioactivity are also properties of these materials. In this study, the latest bioactive materials used, such as Biodentine (a polymeric material with a nanostructure in combination with protein-replants), as well as well-known and common materials that have bioactive properties (such as MTA and calcium hydroxide) were investigated. In addition, the properties and disadvantages of using these materials in dentistry have been stated. These explanations help us to know all the options and materials in our treatments and make a better choice. Based on the results obtained from different studies, new bioactive substances and their effects can cause transformation in different fields of dentistry and solve many problems ahead.
