2023 Volume 11 Issue 2
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Comparative Evaluation of Topical Application of 5-Fluorouracil and Modified Carnoy’s Solution in Management of Odontogenic Keratocyst


Nilesh Mishra, Anuj Dadhich, Aadite V. Vande, Harish Saluja, Seemit Shah, Madan Mishra
Abstract

The study was designed to assess the efficacy of topical application of 5-fluorouracil (5-FU) in the management of odontogenic keratocysts (OKC). The prospective, comparative, clinical study was conducted on seventeen patients with non-recurrent, non-syndromic OKC of the mandible who underwent cyst enucleation and peripheral osteotomy, followed by the application of 5-FU (group A, n = 9) and modified Carnoy’s solution (MC) (group B, n = 8). Patients were assessed for nerve paresthesia, recurrence, and bone healing. Intergroup comparison of age, gender, location, and size was done by analysis of variance and Chi-square test. Recurrence was studied by Kaplan-Meier analysis. Bone healing was compared between the groups using an unpaired t-test.

Age of patients ranged from 26-61 years, with male-to-female ratio of 1.8: 1. Patients were followed-up for 43.7 and 47.5 months in groups A & B, respectively. They showed no recurrence in the 5-FU group and 25% (n=2) recurrence in the MC group. Kaplan-Meier analysis showed a disease-free survival probability of 0.9 at 30 months, which reduced to 0.7 at 60 months in group B. Although temporary paresthesia was seen in both group A (28.5%, n=2) and group B (42.8%, n-3), complete recovery was seen in all the patients. Bone healing assessment showed a mean increase in grey-level score by 36.52 ± 2.96 and 34.064 ± 6.52 in groups A and B respectively, which was statistically insignificant (p-value 0.225184). 5-FU is a novel option for the management of OKC. Its use resulted in lower post-operative paresthesia with no recurrence.


How to cite this article
Vancouver
Mishra N, Dadhich A, Vande AV, Saluja H, Shah S, Mishra M. Comparative Evaluation of Topical Application of 5-Fluorouracil and Modified Carnoy’s Solution in Management of Odontogenic Keratocyst. Ann Dent Spec. 2023;11(2):99-104. https://doi.org/10.51847/exYxyn3qWB
APA
Mishra, N., Dadhich, A., Vande, A. V., Saluja, H., Shah, S., & Mishra, M. (2023). Comparative Evaluation of Topical Application of 5-Fluorouracil and Modified Carnoy’s Solution in Management of Odontogenic Keratocyst. Annals of Dental Specialty, 11(2), 99-104. https://doi.org/10.51847/exYxyn3qWB
Issue 4 Volume 11 - 2023
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