This study aims to consider a systematic review of past literature on this topic. It concentrates on the use of these antibiotics in oral-related research. The study is also focused on analyzing the effectiveness of the prophylactic use of antibiotics and antiseptic Chlorhexidine. This study involves the initial search of relevant past studies on the topic. The research process involved a comprehensive search in medical databases: PubMed, Medline, Google Scholar, and other reliable websites online. The methodology together with the results of the studies were analyzed. The literature obtained is then analyzed and filtered along pre-determined conditions to obtain the most relevant and viable literature to contribute to this systematic review. A total of one thousand seven hundred and fifty literature works were discovered. The studies were then subjected to eligibility criteria to filter invalid studies. The content filtration process bore ten studies for inclusion in the review. The included studies were Random Control Trials (RCTs) and Clinical Trials. Moreover, the studies were directly affiliated with Amoxicillin, Amoxiclav, and Chlorhexidine prophylaxis in preventing oral infection following teeth removal. The systematic review unearthed the major use of Amoxicillin and Chlorhexidine prophylaxis compared to Amoxiclav. Preoperative Amoxicillin prophylactic is an effective measure of reducing unwanted complications after teeth extraction. Chlorhexidine prophylactic isn’t as effective as antibiotics, but it is also a quick and easy step to incorporate into the procedure with minuscular risks associated.
