The article presents for the first time indicators of the state of peri-implant tissues and oral hygiene in users of prosthetic implants, depending on the clinical and operational conditions: compliance with the terms of medical examination, the presence of periodontal diseases, the level of individual oral hygiene. Long-term clinical and radiological indicators of the effectiveness of prosthetics on implants, index indicators of hygiene, and condition of periodontal and peri-implant tissues were studied. The factors and the degree of decrease in the effectiveness of implantation, hygiene, and periodontal indices in patients with dentures on dental implants are described. The results of the analysis of the role of systematic medical examination, professional oral hygiene, and full-fledged individual hygiene in maintaining hygienic and periodontal indicators for users of prosthetic implants are presented. The article describes the effectiveness of various types of individual oral hygiene, including interdental products, irrigators, and “Phagodent” gel-based on bacteriophages in individuals with dental implants. A subjective assessment of the hygienic aspects of prosthetics on implants in people with high motivation to care for the oral cavity and those who do not comply with the terms of medical examination and professional hygiene is put up for discussion.