Periodontitis and gingivitis poorly impact patients' function and appearance, directly affecting their Oral Health-Related Quality of Life (OHRQoL). Systemic problems, including poor pregnancy outcomes, cardiovascular diseases, type 2 Diabetes Mellitus (DM), respiratory disorders, deadly pneumonia in hemodialysis patients, chronic renal disease, and metabolic syndrome, have all been linked to periodontitis. The Medline, Pubmed, Embase, NCBI, and Cochrane databases were searched for studies of patients with non-alcoholic fatty liver disease. Incidence, etiology, and management options were analyzed. At this stage, it is clear that dental plaque (a microbial biofilm) causes gingival inflammation, and the extent and severity of the inflammation are influenced by various systemic and oral factors. Furthermore, plaque accumulates faster in inflamed gingival sites than in non-inflamed sites, resulting in a complex dynamic between the dental plaque biofilm and the host's immune-inflammatory response. However, it should be noted that not all inflammatory sites will progress to periodontitis. treating gingivitis with appropriate local therapeutic intervention is still necessary to prevent attachment loss and destruction of periodontal tissue. Gingival conditions may be diagnosed in the future using objective analytic approaches such as transcriptome characterization or epigenetic change categorization.
