Resin-based sealants and glass-ionomer-based sealants have emerged as the two sealants that can be relied upon to prevent dental caries. Resin-based sealants have been considered the most effective when it comes to the prevention of occlusal carious lesions. Despite this consideration, the literature highlights that these sealants are characterized by hydrophobic properties that necessitate a “near-total moisture control,” an aspect that limits the clinical application of Resin-based sealants. This study aimed to compare the longevity of two pit and fissure sealants: Resin-Based Sealants and Glass Ionomer Sealants. A systematic review approach was used. The PRISMA guidelines guided the literature search to obtain reliable information based on the metrics for exclusion and inclusion of studies. The current study established to despite the widespread use of different pit and fissure sealants, resin-based sealants are better than glass ionomer sealants based on retention. Resin-based sealants are more successful than glass ionomer sealants founding on efficacy and longevity.