Healing of periapical lesions is one of the main goals of root canal therapy. Due to its many advantageous qualities, EndoSequence BC Sealer constitutes a group of materials that can be considered a breakthrough in endodontics. This retrospective investigation aimed to compare the periapical healing rates of root canal treatments utilizing Bioceramic and AH+ sealers in Saudi Arabian patients. The investigation included 171 teeth, and the duration of follow-up ranged from 1 to 4 years. Radiographic evaluation of the healing status revealed no significant difference in root canal treatment success rates between Bioceramic and AH+ sealers for both anterior and posterior teeth. However, the healing rate of anterior teeth was substantially higher than posterior teeth. In addition, there was a faint positive correlation between treatment follow-up time and healing status, but the correlation was not statistically significant. These results indicate that both Bioceramic and AH+ sealers can effectively attain periapical healing; however, additional research is required to identify other factors that may influence the success of root canal treatment in Saudi Arabian patients.
