Artificial intelligence (AI) is getting more popular in the public and healthcare sectors, specifically in dentistry. Therefore, this systematic review seeks to determine the impact of orthognathic surgery on facial symmetry and explore how AI can be employed in evaluating the changes in a human face. The systematic review was carried out adhering to PRISMA guidelines. This systematic review included three studies (two retrospective studies and one proof-of-concept study) that state that AI is an important tool for assessing facial symmetry after surgeries. Deep learning models have great potential to predict, evaluate, and analyse outcomes because subjective factors do not constrain them. It is established that orthognathic surgery improves facial symmetry, and AI is used to plan, predict, and analyze the outcomes of surgeries. Consequently, there is a wide range of applications for AI and this systematic review focused on a narrower area: facial symmetry. Besides, AI needs some control nowadays because there are different AI software, which could have varied capabilities, algorithms, and biases.