Mucormycosis is a rare fungal infection of the craniofacial region and lungs. An upsurge in the cases of mucormycosis was observed in the patients who had a history of SARS-CoV-2 infection.Infact in India, mucormycosis was declared an epidemic during the second wave of the COVID-19 pandemic. Rhino-orbital and cerebral regions were most commonly involved and very few cases of mandibular involvement have been reported in Post-COVID-19 Mucormycosis in India. Herewith, we report a case of isolated mandibular mucormycosis in a COVID- 19 patient. A 47-year-old patient who recently recovered from COVID-19 presented with typical symptoms of osteomyelitis which was confirmed by radiological findings. An incisional biopsy followed by histopathologic examination confirmed mucormycosis of the mandible. Mucormycosis is an aggressive fungal infection thatrequires prompt diagnosis and treatment. Judicious management of osteomyelitis with secondary fungal infections involving the maxilla or mandible in patients with a history of SARS-CoV-19 infection can improve prognosis.