The jaw (ONJ) Osteonecrosis is the most common hurdle in patients taking anti-resorptive, antiangiogenic, immunosuppressive, and chemotherapeutic drugs. Knowledge of these medications is essential for dental practitioners. There are no studies on this subject conducted in Saudi Arabia. This study aims to raise awareness and assess the knowledge and attitude of dental practitioners toward MRONJ. This cross-sectional descriptive observation was conducted through an analysis targeting the 5th and 6th-year dental students and interns randomly selected during the oral surgery session in KAUDH. The Total sample population included 219 students and interns; 73 participants in each level. The questionnaire totals 16 questions applied by one single researcher. A total of 72.1% of participants recognized which dental procedures might be risky for the development of MRONJ, while 40.6% were aware of the other factors associated with increasing MRONJ. Management of MRONJ included 32.4% positive response, and only 36.5% of participants were able to identify all medications other than Bisphosphonates which constituted 49.3% of the total sample. Concerning staging, severity, clinical, radiographic findings, and preoperative referral, the difference among the 3 groups was statistically significant. Many of the interviewees were unaware of the prevention and management of MRONJ, and 79.5% were seeking further information. We recommend that effective initiatives are needed to expand, reinforce and integrate the knowledge for better care of the patients.