Today, end crowns are broadly used as alternatives to the traditional fixed partial and post-core dentures. Mechanically, a conventional endodontic fabricated cavity has minimal fractural resistance to a given tooth. On the other hand, ceramic endocrowns’ thickness of the occlusal portion is usually between three and seven millimeters. Empirical studies have demonstrated that the fracture resistance of ceramic endocrowns intensifies when occlusal thickness increases. This systematic review aimed to determine the association between mechanical properties and occlusal fit to CAD/CAM Designed ceramic endocrowns’ success rates. Systematic review and PRISMA meta-analysis guidelines were adopted to collect relevant studies with accurate information. The primary investigator described in detail the adopted research approach, inclusion, and exclusion criteria. Furthermore, the author explained the Cochrane risk of bias assessment of the selected studies in a tabulated format. 13 peer-reviewed articles were selected after a procedural screening based on the inclusion criteria. The findings and objectives of each study were tabulated for a straightforward interpretation of the outcome. The discussion provided insights into the topic based on the interpretation and critics of the empirical findings. In conclusion, CAD/CAM Designed ceramic endocrowns were found to be the most successful restoration tools in contemporary prosthodontics.