Endodontic and periapical diseases are often caused by pulp infections, in dentistry, antibiotics are not commonly prescribed because surgical intervention is usually needed for inflammatory oral diseases. Antibiotics can be used as an additional treatment for localized lesions and orofacial infections. Implementing a training program in microbiology and immunology for dental students and practitioners can help improve antibiotic prescription practices and raise treatment standards in Saudi Arabia. To assess knowledge and awareness level about antibiotics prescription in endodontic treatment among general dentists in KSA. A 14-questioned cross-sectional questionnaire survey was conducted in Saudi Arabia, and was circulated among general dentists consisting general-knowledge questions about antibiotics where participants were asked to indicate whether an antibiotic prescription was necessary or not. Information was collected through surveys using SPSS version 25.0. The study included 460 participants, 71.7% of whom were females. The majority of participants fall within the 20-30 years age bracket, accounting for 82.6% of the total. The majority of the population, comprising 47.4%, is in the high knowledge level category, followed by moderate and low knowledge level categories at 38.0% and 14.6%, respectively. All sociodemographic characteristics showed a statistically significant association with knowledge level. The study showed that participants exhibited sufficient knowledge regarding antibiotic-prescribed related endodontic treatment; however the study highlights the need for continued education and training for general dentists on the appropriate use of antibiotics in endodontic treatment.
