Temporomandibular joint disorders are a group of conditions that affect a large portion of the general public. It is characterized by orofacial pain that increases in intensity with jaw movement. The diagnosis is purely clinical. Self-care and NSAIDs have been a huge part of the management of this condition. In addition, due to the musculoskeletal nature of the condition, Botulinum injection has been theorized to have a role in the management of this condition. We aimed to review the literature reviewing temporomandibular joint disorders’ epidemiology, clinical manifestation, diagnosis, and management. We also looked into the recent studies showing the efficacy of Botox injection in the management of this condition. PubMed database was used for articles selection, and papers were obtained and reviewed. TMD is associated with high morbidity. Thus, proper management is key whenever physicians encounter this condition. Self-care techniques, along with pain relief with NSAIDs, have been the mainstay of therapy for this condition. Other options include muscles relaxants and Botox injection for persistent cases. However, due to the subjectivity of pain, most of the published research into the efficacy of Botox resulted in inconclusive data. Further studies are required before considering Botox as first-line therapy.