This systematic review investigated the efficacy and clinical properties that make Ionoseal a successful sealing and lining agent during dental restorations. The study relied on secondary data compilation and analysis; thus, PRISMA meta-analysis and systematic review were adopted as the ideal methodology approaches. The research design procedure involved the identification of relevant inclusion and exclusion criteria for article screening and using the Cochrane risk of bias assessment for risk analysis. Tabulation of results, criteria, and results is used for a better presentation of the content. Procedural PRISMA analysis was used to screen many articles before settling on 15 peer-reviewed and scholarly articles based on the set inclusion criteria. The result showed that Ionoseal had a higher comprehensive strength of 226 MPa and transverse strengths of 95 MPa. The empirical findings supported this statistic from a different perspective. Ionoseal is an effective sealing and lining agent because it has high comprehensive and transverse strengths, great acid resistance, microorganisms’ leakage preventer, high bonding and flexural strengths, and esthetic dentistry.
