The purpose of this study was to assess the efficacy of calcium silicate-based sealers using a systematic review methodology. The literature search was done online, focusing on websites such as Google Scholar, Biomedical Central, Science Direct, Pub Med, CINAHL, and Medline. There is a need for future research to pay attention to these areas. The included sources need to be peer-reviewed journals. The articles should be reports arising out of primary research. The articles of priority were full-text articles. Sources of information published have to be within the last five years. The participants were patients with deep dental carriers who need root canal treatment. The intervention was calcium silicate-based sealers. The evaluation of 11 articles yielded several observations. Firstly, calcium silicate-based sealers are found to be viable alternatives to conventional sealers, albeit with a few weaknesses that should be considered. Secondly, the effectiveness of a particular calcium silicate-based sealer depends on the chemical formula. Thirdly, this efficacy can be best deduced from the lenses of two concepts: safety and versatility. The paper performed a systematic review to ascertain the efficacy of calcium silicate-based sealers. The research found that calcium silicate-based sealers are viable alternatives to conventional sealers. Therefore, the intervention has a high level of safety and versatility.