Endodontic infections are difficult and may cause long-term issues as well as accepted consequences. Cleaning the root canals is necessary to keep the tooth in a non-pathological state. Moreover, teeth that are growing and infected may delay the growth of the roots and eventually cause other issues. Anaerobic bacteria that are polymicrobial and required stand out in endodontic infections. Drugs like Ledermix may permeate the cementum and dentinal tubules to reach the periodontal and periapical tissues. Calcium hydroxide, dexamethasone, and triple antibiotic paste seem to help lessen surgical pain, especially in cases with symptomatic irreversible pulpitis. Using the PubMed, Medline, and ScienceDirect databases, a comprehensive evaluation of the literature from 2001 to 2022 was conducted. "Antibiotics, steroids, intracanal medication, and endodontic pain" were the keywords. After the screening procedure, nine studies were included, the majority of which indicated that endodontic pain is greatly affected by the combination of steroids and antibiotics. To investigate the relative efficacy of these drugs in more comprehensive clinical settings, additional investigation is necessary. All things considered, these investigations provide insightful information to the endodontic community, emphasizing the significance of customized intracanal drug selection for the best possible patient results.
