Clinically, an early caries lesion in enamel is initially seen as a white, opaque spot and is characterized by being softer than the adjacent sound enamel and becoming increasingly white when dried with air. The objective of this study is to compare the efficiency of Cervitec® Plus and Fluor Protector® varnish on the incidence of white spot lesions in orthodontic patients. The study was designed as a prospective control trial that included 30 patients. This is a split-mouth study in which Cervitec® Plus varnish was applied to the 1st quadrant and Fluor Protector® varnish to the 2nd quadrant. The enamel fluorescence values were noted using the Diagnodent pen in three-time intervals, where T0 is before bonding, T1 is one month after strap-up, and T2 is two months after strap-up. A paired t-test revealed a significant amount of reduction in the value of enamel fluorescence between the T0 and T2 groups and between the T1 and T2 time intervals in both the Cervitec®Plus and the Fluor Protector® groups. A Mann-Whitney test comparing the Cervitec® Plus group with the Fluor Protector® group showed no significant difference between the two groups. There is no significant difference between the Cervitec® Plus varnish and Fluor Protector® varnish in reducing the incidence of white spot lesions in patients undergoing orthodontic treatment. Thus, the use of these varnishes (Cervitec® Plus and Fluor Protector®) to prevent and, in some cases, manage white spot lesions in patients undergoing orthodontic treatment can be encouraged.