Pregnancy may cause changes in the oral cavity because of physiological factors. Tooth loss during pregnancy is a common oral health concern. Our study aimed to review the literature for determinants of tooth loss during pregnancy. We searched MEDLINE, Cochrane, CINAHL via EBSCOhost, ScienceDirect, and Google Scholar. Six relevant articles were included in the review. Several factors were significantly associated with tooth loss among pregnant women. The demographic factors included parity, place of residence, and household size. The psychological factor was defined by lifetime anxiety. The dietary factors included the intake of magnesium and the consumption of vegetables other than those that are yellow and green. The behavioral factors included active smoking, passive smoking, and the duration since the woman’s last dental visit. Our findings suggest that it is imperative to provide oral health education during prenatal visits. Other recent and well-designed studies are needed to confirm the findings of this review. Understanding the mechanisms underlying tooth loss during pregnancy is critical to design successful prevention and intervention programs that can improve maternal and child health outcomes.