This study aims to evaluate the knowledge and attitude toward mental illness among dental students and interns. To examine dental students’ knowledge and attitude about mental disorders, a self-administered questionnaire was designed, tested, and disseminated to dental students and interns through social outlets, participation was voluntary after consenting. A total of 125 dental students and interns participated in the study. Data were statistically analyzed using SPSS. Our results displayed that more than half of the sample attended an educational course about mental illness. Almost 40% of the participants have encountered patients or individuals with mental illness. The results also indicated that there is deficient information but a positive attitude. There was also a lack of knowledge about medications' side effects. Knowledge and attitude were affected by gender and academic level. It also revealed stigmatization among the participants. Our study disclosed the importance of academic education during courses and continuing professional education. This may aid in reinforcement of knowledge since the majority has a positive attitude.