The occurrence of oral infections could be a prerequisite for the development of systematic diseases which predefines their prophylaxis as a priority. Among the most frequent oral cavity diseases in complete denture wearers is denture stomatitis. The elaboration of removable dentures made of materials that have antimicrobial effects is a possible way to prevent this disease. The present review researches the data in dental literature about the various types of modified denture materials, their antimicrobial properties, advantages, and disadvantages. Additionally, we have discussed the issues remaining unclear in view of their clinical application. To this end, e-search was performed in four databases: PubMed, Web of Science, Google Scholar, and Scopus. Within the range of this research, we could conclude that via the inclusion of various modifying agents significant number of denture materials with proven antimicrobial properties have been invented. The established positive effects of suppressing the development of pathogens that cause denture stomatitis is a prerequisite for these materials to be included as a component in contemporary strategies for disease prevention. In order to be successfully integrated into routine dental practice, we need additional clinical research to clarify the antimicrobial effectiveness of different materials in real conditions of the oral cavity and after taking into consideration the impact of the accompanying general and local factors.