This review explores the diverse modes of cell communication in dental tissues, encompassing direct cell-to-cell interactions through gap junctions and tight junctions and indirect signaling mediated by soluble factors like cytokines, growth factors, and neurotransmitters. Special emphasis is placed on the role of cell communication in key dental processes, including odontogenesis, tooth eruption, and periodontal tissue remodeling. Furthermore, the dysregulation of cell communication pathways is implicated in various dental disorders, including caries, periodontal diseases, and craniofacial abnormalities. Understanding the molecular intricacies of cell-to-cell communication provides valuable insights into the etiology and potential therapeutic interventions for these conditions. In conclusion, deciphering the complexities of cell-to-cell communication in dental tissues enhances our understanding of normal physiological processes and offers promising avenues for targeted therapies in dental medicine. This review consolidates current knowledge on cell communication mechanisms, shedding light on their relevance to dental tissue biology and their potential implications for clinical practice and future research endeavors.
