For the past century, the researcher began looking into the effect of fluoride on oral health and hygiene. Topical fluoride treatment has been found to prevent dental caries in children by 25%. After that discovery, fluoride was implemented into the drinking water supply and toothpaste to fight off caries in children and adults. Fluoride makes enamels more resistant to an acidic environment and inhibits bacterial enzymes by replacing OH- by F- in hydroxyapatite making fluorapatite. We reviewed the literature reviewing Enamel fluoride uptake from different fluoride dentifrices. PubMed database was used for articles selection, and papers were obtained and reviewed. Toothpaste remains one of the integral ways of introducing fluoride, and thus the enamel fluoride uptake from them is crucial. In conclusion, this mechanism depends on many factors, starting from the concentration, length of brushing, and up to pH of the toothpaste. Nevertheless, detailed, thorough studies are still needed to shed light on many other possible factors that may play a role in the enamel fluoride uptake.