Evaluate and compare antimicrobial potency of Zinc oxide eugenol (ZOE), Zinc oxide with Curcumin (ZOC), and Curcumin alone against Enterococcus faecalis (E. faecalis) and Candida albicans (C. Albicans) by using the agar diffusion method. Antimicrobial potency of ZOE, ZOC, and Curcumin gel were assessed and compared with each other against C. Albicans and E. faecalis. Muller Hinton agar was punched at equidistant points into which test materials were filled for both microorganisms and incubated at 37ºC for 24 hours. Antimicrobial efficacy was assessed with disk diffusion in Agar. ANOVA and Post-Hoc Tests (Tukey-HSD) were used for statistical analysis. Highest antimicrobial potency in terms of inhibition zones were obtained with ZOE followed by an equivalent zone of inhibition with ZOC and Curcumin alone against C. Albicans. The highest antimicrobial potency in inhibition zones was obtained with ZOE, followed by Curcumin alone and ZOC against E.faecalis. A significant difference is present between ZOE and ZOC, ZOE and Curcumin. No significant difference was found between ZOC and Curcumin against C. Albicans and E. faecalis. In-vitro antibacterial activity of ZOE is consistent against E. faecalis and C. Albicans. ZOC and Curcumin alone exhibits satisfactory antibacterial activity and can be further considered as an alternative obturating material in impending future.
