This study aims to assess and correlate the existing relationship between cuspal angulation and condylar guidance in natural dentition. 56 Pretreatment samples (lateral Cephalogram and study models) of subjects were included in this study. The Cuspal angulation was measured by 3dimensional technology by scanning the study model. Cuspal angulation is formed by the inclination of the cuspal slope and the line passing through the cusp fossa of a respective tooth. For measuring cuspal angulation, the study model is scanned by an extra-oral scanner (shinning 3d auto scanner). STL image of the study cast was obtained and with the help of haptic device cuspal angulation is measured in a cross-section manner. Condylar guidance was measured on Lateral Cephalogram, as the angle between the line tangential to the posterior slope of articular eminence and Frankfort horizontal plan was obtained. The Statistical analyses were taken using Statistical Package for the Social Sciences SPSS software. The measured values were subjected to a Bivariate Correlation test and evaluated the correlation by the scatter plot test. A p-value more than 0.05 was considered to be statistically non-significant. Bivariate Correlation analysis reveals that Pearson’s Correlation coefficient between cuspal angulation and condylar guidance is 0.117 (P= 0.41). There is no statistically significant correlation between factors that are usually changed during orthodontic treatment.