TY  - JOUR
T1  - Systemic Boric Acid and Rhbmp-2-Induced Alveolar Bone Healing and Osteogenic Activity After Tooth Extraction in Wistar Rats
A1  - Christian Khoswanto
A1  - Oki Fadhila
A1  - Setyabudi Setyabudi
JF  - Annals of Dental Specialty
JO  - Ann Dent Spec
SN  - 2347-2022
Y1  - 2026
VL  - 14
IS  - 4
DO  - 10.51847/q0YiS5TEdA
SP  - 14
EP  - 21
N2  - The aim of this study was to assess the systemic use of boric acid, local use of rhBMP-2, and the combination of systemic boric acid and local rhBMP-2 for their effect on osteoblast activity and osteocalcin (OCN) expression in maxillary extraction socket in Wistar rats. The rats were divided into Control group (C), boric acid (BA) group, rhBMP-2 group and BA + rhBMP-2 group. After the extraction of first maxillary molar, BA was given at the dose of 50 mg/kg/ day. A sterile sponge was used to locally deliver rhBMP-2 at a nominal dose of 0.25 µg per sponge. The animals were assessed on Days 10 and 20. Two-way ANOVA and Tukey's post-hoc test were used for data analysis. Osteoblast numbers and OCN expression were significantly affected by treatment, time, and treatment × time interaction. Systemic boric acid enhanced the osteogenic response associated with local rhBMP-2 during extraction socket healing. Combined treatment produced the greatest osteoblast activity and OCN expression, supporting boric acid as a potential systemic adjunct to rhBMP-2-mediated alveolar bone regeneration.
UR  - https://annalsofdentalspecialty.net.in/article/systemic-boric-acid-and-rhbmp-2-induced-alveolar-bone-healing-and-osteogenic-activity-after-tooth-ex-riq2hy1nck71mr3
ER  -