%0 Journal Article
%T Integration of Regenerative Techniques in the Treatment of Periodontal Conditions: Meta-Analysis
%A Gulshakhar Karkimbayeva
%A Zhanagul Rysbayeva
%A Gulbanu Dosberdiyeva
%A Sholpan Askarova
%A Anara Uatayeva
%J Annals of Dental Specialty
%@ 2347-2022
%D 2025
%V 13
%N 4
%R 10.51847/3IPTVp0u9M
%P 6-15
%X This meta-analysis evaluated the clinical efficacy of regenerative therapies for periodontal treatment, focusing on clinical attachment level gain and probing pocket depth reduction. A comprehensive literature search was conducted across Web of Science, Scopus, PubMed, Cochrane Library, and Google Scholar. Thirty-one studies published between 2019 and 2025 were included. Data analyses were performed using RevMan 5.4. The studies followed a PRISMA approach to ensure systematic reporting and consistency in methodology. The pooled results demonstrated that regenerative interventions significantly improved CAL gain (MD: 0.41 mm; 95% CI: 0.12-0.70; I² = 78%), with platelet derivatives (MD: 0.45 mm; 95% CI: 0.04-0.86; I² = 54%) and hydrogel-based therapies (MD: 0.53 mm; 95% CI: 0.03-1.04; I² = 71%) showing the most consistent benefits. PPD reduction was modest (MD: 0.06 mm; 95% CI: -0.23-0.35; I² = 84%), with platelet derivatives providing better outcomes (MD: 0.38 mm; 95% CI: -0.13-0.89; I² = 67%). Growth factor interventions improved CAL (MD: 0.21 mm; 95% CI: -0.26-0.67; I² = 48%) but showed variable PPD outcomes, while biomaterial-based scaffolds showed limited efficacy. Growth factor therapies improved CAL but produced variable PPD changes. Overall, findings support hydrogel- and platelet-based regeneration, highlighting the need for combined strategies, digital guidance, and extended follow-up for durable clinical outcomes.
%U https://annalsofdentalspecialty.net.in/article/integration-of-regenerative-techniques-in-the-treatment-of-periodontal-conditions-meta-analysis-kfuelabeuzu4fp9