%0 Journal Article
%T Efficacy of Linezolid-Based Hydrogel as Local Drug in Stage II Grade A Periodontitis-A Clinical Study
%A Poulami Chakraborty
%A Arvina Rajasekar
%J Annals of Dental Specialty
%@ 2347-2022
%D 2024
%V 12
%N 1
%R 10.51847/BUnKMJeFfH
%P 1-6
%X To prepare and characterize linezolid-based hydrogel and evaluate its efficacy as local drug delivery in stage II grade A periodontitis. Linezolid-based hydrogel was prepared. Hemolysis assay was done at various concentrations (2%, 4%, 6%, 8%, 10%) and a biocompatibility test was performed by MTT Assay. Forty patients with stage II grade A periodontitis were involved in this clinical trial. Participants were split into two groups. Group A (control) received only scaling and root planing (SRP) and Group B (test) received linezolid gel along with SRP. Clinical data were recorded, including plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) at baseline and after 3 months. In vitro analysis revealed that at 2% concentration, the hemolysis ratio was less than 1% and 98% cell viability was observed after 94 hours in biocompatibility assay. 2% Linezolid-based hydrogel was subjected to in vivo analysis. Upon intra-group comparison, all the clinical parameters (PI, GI, PPD, CAL) showed statistically significant differences (p
%U https://annalsofdentalspecialty.net.in/article/efficacy-of-linezolid-based-hydrogel-as-local-drug-in-stage-ii-grade-a-periodontitis-a-clinical-stud-r7mintdfvjioazn