TY  - JOUR
T1  - Ecological Dynamics of the Oral Microbiome: A Systems-Based Model of Dysbiosis, Biofilm Maturation, and Host Inflammatory Response
A1  - Lucas Meyer
A1  - Anna Schmid
A1  - Stefan Braun
JF  - Annals of Dental Specialty
JO  - Ann Dent Spec
SN  - 2347-2022
Y1  - 2025
VL  - 13
IS  - 3
DO  - 10.51847/VPwZBcYI22
SP  - 144
EP  - 152
N2  - The oral microbiome is a complex ecological system in which microbial communities interact dynamically with the host environment, influencing health and disease. This conceptual manuscript proposes a systems-based model to elucidate the ecological dynamics of the oral microbiome, focusing on the interplay between dysbiosis, biofilm maturation, and host inflammatory responses. Drawing on recent advances in microbial ecology, the model integrates microbial colonization stages, community shifts toward pathogenic dominance, and the resulting activation of host immune pathways. Key elements include environmental factors such as pH fluctuations and nutrient availability that drive biofilm development from initial adhesion to mature polymicrobial structures. Dysbiosis emerges as a tipping point where resilient commensal networks give way to opportunistic pathogens, exacerbating inflammatory cascades involving cytokines and innate immune effectors. The model highlights feedback loops between microbial virulence factors and host responses, potentially amplifying the progression of periodontal and systemic diseases. By framing these interactions as a nonlinear system, this work underscores the importance of ecological resilience in maintaining oral homeostasis. Implications extend to preventive strategies targeting microbial balance rather than eradication, offering a framework for future interdisciplinary research in oral health sciences. This systems approach provides a holistic view, bridging microbiology and immunology to advance understanding of oral dysbiotic transitions. 
UR  - https://annalsofdentalspecialty.net.in/article/ecological-dynamics-of-the-oral-microbiome-a-systems-based-model-of-dysbiosis-biofilm-maturation-calbtq7zuho13v9
ER  -